ClinicalTrials.Veeva

Menu

The Impact of Supplementation With Hericium Erinaceus (Lion's Mane) Extract on Cognitive Functioning (HECOG)

U

University of Social Sciences and Humanities, Warsaw

Status

Completed

Conditions

Cognitive Function and Well-Being
Memory
Attention

Treatments

Dietary Supplement: Hericium erinaceus Supplementation
Dietary Supplement: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT07405632
GW2 (Other Grant/Funding Number)
Hericium erinaceus - Cognition

Details and patient eligibility

About

The goal of this study is to determine whether supplementation with Hericium erinaceus (Lion's Mane) extract enhances selected cognitive functions in healthy, actively working, middle-aged women. We aim to investigate a broad spectrum of cognitive functions to identify which, if any, are affected both immediately and after prolonged supplementation with Hericium erinaceus extract.

Our main research questions are as follows:

  1. Can Hericium erinaceus extract supplementation modify cognitive status?
  2. Is there an immediate effect on cognition following a single intake of Hericium erinaceus extract?
  3. Does prolonged supplementation with Hericium erinaceus extract influence cognitive functioning?
  4. Which cognitive functions are affected, and will the patterns differ between immediate effects and those observed after long-term supplementation?
  5. Will participants report subjective cognitive enhancement?

Our main hypotheses are as follows:

  1. A single dose of Hericium erinaceus extract will produce an acute effect, improving attention 45 minutes after intake.
  2. An eight-week supplementation period with Hericium erinaceus extract will produce a chronic effect, improving long-term memory.
  3. The investigators will compare Hericium erinaceus extract with a placebo (a visually identical substance that contains no active ingredients) to determine whether the extract effectively enhances cognitive functioning.

Participants will:

  1. Take a Hericium erinaceus extract or placebo capsule daily for 2 months.
  2. Visit SWPS University for baseline assessments before beginning supplementation (T0), a follow-up assessment 45 minutes after the initial intake (T1), and additional assessments at 1 week (T2) and 2 months (T3).
  3. Complete neuropsychological testing and questionnaires during the T1, T2, and T3 visits.
  4. Maintain their usual dietary habits throughout the study.

Enrollment

85 patients

Sex

Female

Ages

30 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

- residing in Warsaw, Poland or the surrounding area.

Exclusion criteria

  • pregnancy or lactation,
  • history of head injury with neurological consequences,
  • history of neurological disorders or diseases,
  • chronic use of antibiotics,
  • use of antibiotics within the last 30 days,
  • chronic use of antifungal medications,
  • use of antifungal medications within the last 30 days,
  • allergies or intolerance to mushrooms (especially Lion's Mane),
  • consumption of caffeinated beverages (e.g., coffee, energy drinks) prior to the study visit.

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

85 participants in 2 patient groups, including a placebo group

Hericium erinaceu
Experimental group
Description:
This is a group of participants who will receive Hericium erinaceu during the duration of the study.
Treatment:
Dietary Supplement: Hericium erinaceus Supplementation
Placebo
Placebo Comparator group
Description:
This is a group of participants who will receive placebo during the wole duration of the study.
Treatment:
Dietary Supplement: Placebo

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2026 Veeva Systems