The Impact of the Opiate Antagonist Naltrexone on the Emotional Valence of Dreams

University of Bern

Status and phase: Completed; Phase 4

Conditions: Neuroscience of Dreaming, Healthy

Treatments: Other: Placebo; Drug: Naltrexone

Study type: Interventional

Funder types: Other

Identifiers

NCT02792140

2015DR2186

Details and patient eligibility

About

In this study, the investigators pose the question which influence the opioid circuit has on positive valent situations in dreams.

Enrollment: 32 patients

Sex: Male

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Written informed consent
• Healthiness
• Good capacity of remembering dreams
• No opiate consumption

Exclusion criteria

• Simultaneous participation in other studies
• Addictive disorder
• Abnormal liver function
• Abnormal kidney function
• Hypersensitivity to active ingredient or pharmaceutical additives
• Hereditary galactose intolerance
• Lactase deficiency
• Glucose-galactose malabsorption
• Intake of opioid medication

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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32 participants in 3 patient groups, including a placebo group

Baseline

No Intervention group

Description:

reporting of dreams

Naltrexone

Experimental group

Description:

daily administration of 50mg Naltrexone, reporting of dreams

Treatment:

Drug: Naltrexone

Placebo

Placebo Comparator group

Description:

daily administration of Placebo, reporting of dreams

Treatment:

Other: Placebo