The Impact of the SCN9A Gene Polymorphism on Postoperative Pain

Tokat Gaziosmanpasa University

Status: Completed

Conditions: Pain, Postoperative; Pregnancy

Treatments: Procedure: cesarean section; Drug: Opioid Tramadol

Study type: Observational

Funder types: Other

Identifiers

NCT02496455

GEN-S

Details and patient eligibility

About

The purpose of this study to determine the association between postoperative pain after cesarean section and several single nucleotide polymorphisms in SCN9A sodium channels gene.

Full description

SCN9A gene encodes an alpha subunit of the voltage-gated sodium channel (Nav1.7) and polymorphisms of this gene are associated with severe pain disorders. The impact of the polymorphisms in SCN9A on postoperative pain and opioid consumption after cesarean section is unclear.

Enrollment: 200 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The women aged 18 to 45,
• in 36 to 40 weeks of pregnancy
• undergoing cesarean section

Exclusion criteria

• History of chronic pain or pain disorders
• Psychiatric diseases
• Diabetes mellitus
• Severe cardiovascular, kidney or liver diseases
• Alcohol or drug abuse
• Heavy smoker
• Unable to use the Patient controlled analgesia (PCA) pump