The Impacts of Theta-burst Stimulation on Children and Adolescents With Autism Spectrum Disorder

Chang Gung Medical Foundation

Status: Completed

Conditions: Autism Spectrum Disorder

Treatments: Device: intermittent theta burst stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT03621189

201509413A0

Details and patient eligibility

About

The investigator would like to investigate the impact of theta-burst stimulation over posterior superior temporal sulcus in children and adolescents with autism spectrum disorder

Enrollment: 80 patients

Sex: All

Ages: 7 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• autism spectrum disorder, confirmed by ADOS

Exclusion criteria

• current and past systemic disease
• current and past major psychiatric disorders including schizophrenia, bipolar affective disorder and major depressive disorder
• current and past brain injuries
• intelligence < 70
• seizure history
• pregnant

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 2 patient groups

Active-Active

Active Comparator group

Description:

Participants received the real intervention of TBS (iTBS 1200) over the posterior superior temporal sulcus for 8 weeks (2 days/week). \*iTBS = intermittent theta burst stimulation

Treatment:

Device: intermittent theta burst stimulation

Sham-Active

Sham Comparator group

Description:

Participants received the sham intervention of TBS (coil tilted one-wing 90° off the head) over the posterior superior temporal sulcus for 4 weeks (2 days/week) and then received the real intervention of TBS (iTBS 1200) over the posterior superior temporal sulcus for 4 weeks (2 days/week). \*iTBS = intermittent theta burst stimulation

Treatment:

Device: intermittent theta burst stimulation