The Implementation of Novel 'Heavy' Water Techniques for Determining Modulation of Muscle Protein, DNA and Lipid Synthesis Due to Ageing

University of Nottingham

Status

Completed

Conditions

Healthy

Treatments

Behavioral: Resistance Exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT02152839

Physoc_D20

Details and patient eligibility

About

Maintenance of body's skeletal muscle is key to a healthy older age. However, as we age we lose on average 1-2% of our muscle each year. In order to slow this loss we need to understand fully the mechanisms regulating muscle mass with ageing. In this project we aim to determine these mechanisms using a new novel technique of 'heavy' water ingestion, which will allow us to measure multiple aspects of skeletal muscle mass control during normal everyday activities in young and old individuals over a period of 6 weeks. We will also determine the influence of resistance exercise training during this period in offsetting declines in muscle with ageing using this method

Enrollment

20 patients

Sex

Male

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Young (18-30y) and old men (65-75y) who are generally healthy and recreationally active

Exclusion criteria

Active cardiovascular disease
Cerebrovascular disease including previous stroke, aneurysm (large vessel or intracranial)
Respiratory disease including pulmonary hypertension or COPD
Hyper/ hypo parathyroidism, hyper/ hypothyroidism, Cushing's disease, diabetes
Active inflammatory bowel disease
Renal disease
Malignancy
Recent steroid treatment (within 6 mo), or hormone replacement therapy
Clotting dysfunction
Musculoskeletal or neurological disorders
Any disease requiring long-term drug prescriptions, including statins