The IMPROV Project: Improving Mental Health and Substance Use Treatment Provision (IMPROV) Among People Living With HIV (Human Immunodeficiency Virus) in Atlanta

RTI International

Status: Not yet enrolling

Conditions: Implementation Science; Mental Health Disorder; Substance Use Disorder; Stigmatization

Treatments: Behavioral: Modified Health Policy Project (HPP) HIV-Stigma and Discrimination Reduction Training Curriculum; Device: You℞ Decision prescribing platform

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT05415891

Pro00063322

R34MH124628 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This project consists of a pilot trial to assess the preliminary impact of a stigma-reduction training to reduce clinic-level stigma and the You℞ Decision prescribing platform to increase HIV care providers' self-efficacy related to prescribing psychiatric medication for depression, post-traumatic stress disorder (PTSD), and bipolar disorder as well as naltrexone for alcohol use disorder (AUD).

Full description

The study will pilot test a two-level strategy to improve integration of pharmacotherapy for serious mental health and alcohol use disorders among people living with HIV (PLHIV) in Ryan White-funded healthcare centers in Atlanta, Georgia. A small pilot trial will be conducted in the two clinic study sites to assess the acceptability, feasibility, adoption, and preliminary impact of a stigma-reduction training and the You℞ Decision prescribing platform.

The researchers will fulfill the purpose of this study through the following aims:

Aim 1: To conduct formative activities with PLHIV, HIV care providers, and our Community Collaborative Board (CCB) to adapt a stigma-reduction training to address mental health and substance abuse-related stigma among clinic staff and engage HIV care providers and an expert panel to develop the You℞ Decision prescribing platform to support HIV care providers to offer pharmacotherapy to treat depression, PTSD, bipolar disorder, and AUD (completed).

Aim 2: To assess the acceptability of the stigma-reduction training among clinic staff and the feasibility, acceptability, and adoption of the You℞ Decision prescribing platform during clinical encounters among providers in HIV care settings.

Aim 3: To use idiographic methods to conduct a pilot trial to assess the preliminary impact of the stigma-reduction training on clinic-level stigma and of the You℞ Decision prescribing platform on HIV care providers' self-efficacy to prescribe psychiatric medications and naltrexone as well as the impact of the stigma-reduction training and platform to increase the percentage of eligible patients who receive and accept prescriptions to treat depression, PTSD, bipolar disorder, and AUD.

This implementation science study aims to reduce HIV-associated comorbidities by improving the integration of mental health and AUD treatment into Ryan White-funded care sites. If the findings indicate that the stigma-reduction training and prescribing platform are feasible, this study will be the impetus for the scale up these strategies to additional Ryan White-funded care sites in Georgia.

Enrollment: 333 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Stigma Reduction Training

• be 18 years of age or older
• be a staff member at the clinic study site randomized for the stigma-reduction training

Clinic Staff Survey

• work at one of the two clinic study sites
• be 18 years of age or older

Patient Survey

• 18 or older
• report being HIV positive
• have received care from a clinic study site recently

Pilot Trial

• provide HIV care
• be 18 years of age or older
• be licensed to provide prescription medication
• provide care at one of the two clinic study sites

Exclusion criteria

Stigma Reduction Training

• Have been part of the formative activities

Clinic Staff Survey

• Have been part of the formative activities.

Patient Survey

• HIV negative
• Have not attended a study clinic site recently
• Have participated in the formative activities

Pilot Trial

• Not a prescribing provider
• Not a provider at a study clinic site recently
• Have been part of the formative activities

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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333 participants in 2 patient groups

Stigma-Reduction Training Arm + YouRx Prescribing Platform

Experimental group

Description:

Staff working in the clinic in this arm will be offered a whole-site stigma reduction training. Participating HIV care providers will have access to the YouRx Prescribing Platform.

Treatment:

Device: You℞ Decision prescribing platform

Behavioral: Modified Health Policy Project (HPP) HIV-Stigma and Discrimination Reduction Training Curriculum

YouRx Prescribing Platform Only

Experimental group

Description:

Staff working in the clinic in this arm will not be offered a whole-site stigma reduction training. However, staff will be offered this training at the conclusion of the study. Participating HIV care providers will have access to the YouRx Prescribing Platform.

Treatment:

Device: You℞ Decision prescribing platform