The Improvement of Black Raspberry in Obese and Mild AZ Patients Infected With H. Pylori (BR)

Chung Shan Medical University

Status: Completed

Conditions: Alzheimer Disease; H Pylori Infection

Treatments: Other: Placebo; Dietary Supplement: Black raspberry

Study type: Interventional

Funder types: Other

Identifiers

NCT05680532

CS2-21103

Details and patient eligibility

About

The current study was designed to check the impact of black raspberry (BR) on obese and mild Alzheimers (AZ) patients infected with Helicobacter pylori (H pylori). Through checking various parameters including anthropometric, antioxidants, and CDR.

Full description

The current study was designed to check the impact of black raspberry (BR) on obese and mild Alzheimers (AZ) patients infected with Helicobacter pylori (H pylori).

Preclinical studies (In vitro model) were conducted using 3T3-L1 adipocyte cells to check the anti-adhesion activity of BR.

For the clinical trial, a total of 21 obese mild AZ patients were recruited and separated into 2 groups: Experimental (BR group) and Placebo group.

Experimental group and Placebo group subjects were requested to take either 50 g of BR or 50 g of dextrin respectively for 4 weeks.

Enrollment: 21 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI ≧ 27, Waist circumference: men ≧ 90cm, women ≧ 80cm,
• Body fat: male ≧ 25%, female ≧ 30%,
• UBT 13C test value> 10‰ (H. pylori (+)),
• CDR (clinical dementia rating) = 0.5

Exclusion criteria

• BMI< 27
• Severe chronic diseases (liver disease, cardiovascular disease, kidney disease)
• Alcohol abuse
• Smoking habit
• Taking berry-related supplementation or any known allergies related to berries.
• Subjects with prior history of H. pylori infection were treated with triple therapy.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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21 participants in 2 patient groups, including a placebo group

BR group

Experimental group

Description:

Experimental group AZ subjects were requested to take 50 g of BR powder dissolved in 240 ml of water for 4 weeks.

Treatment:

Dietary Supplement: Black raspberry

Placebo group

Placebo Comparator group

Description:

Placebo group AZ subjects were requested to take 50 g of dextrin powder dissolved in 240 ml of water for 4 weeks.

Treatment:

Other: Placebo