The Improvement of Intraoperative Neuromonitoring of Recurrent Laryngeal Nerve

Kaohsiung Medical University

Status: Completed

Conditions: Thyroid Intra-Operative Injury

Treatments: Drug: sugammadex

Study type: Interventional

Funder types: Other

Identifiers

NCT03911232

KMUH-IRB-E-20150023

Details and patient eligibility

About

Objectives: The use of neuromuscular blocking agent may interfere with the function of intraoperative neuromonitoring (IONM) in thyroid surgery.

Full description

An enhanced neuromuscular-blockade (NMB) recovery protocol was investigated in a clinically applied during thyroid neural monitoring surgery. In as subsequent clinical application study, 60 patients who underwent thyroidectomy with IONM followed an enhanced NMB recovery protocol- rocuronium 0.6 mg/kg at anesthesia induction and sugammadex 2 mg/kg at operation start. Train-of-four (TOF) ratio was used for continuous quantitative monitoring of neuromuscular transmission.

Enrollment: 60 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing intraoperative neuromonitoring of recurrent laryngeal nerve during thyroidectomy

Exclusion criteria

• Patients with a history of significant cardiac, pulmonary, hepatic, or renal disease, body mass index <18.5 or >35, chronic drug or alcohol abuse

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Enhanced recovery

Experimental group

Description:

rocuronium 2 effective dose at anesthesia induction sugammadex after skin incision and before extubation (total 2 mg/kg iv)

Treatment:

Drug: sugammadex

Conventional anesthesia

No Intervention group

Description:

standard general anesthesia protocol (1 effective dose of rocuronium at anesthesia induction)