The Incidence,Factors,and Importance of Brown Adipose Tissue in Chinese Adults

Fudan University

Status: Unknown

Conditions: Obesity

Study type: Observational

Funder types: Other

Identifiers

NCT01387438

KY2009-279

Details and patient eligibility

About

Previous studies have shown that active brown adipose tissue (BAT) is present in adults and may play important roles in material and energy metabolism. However, most of these studies were tumor-based populations and retrospective study. Due to the large amount in our cohort, the investigators are able to promote a cross-sectional study of the incidence and factors of BAT in adult chinese. In addition, the investigators can analyse the metabolic profiles in healthy adults with active BAT.

Full description

The investigators will perform a cross sectional analysis on the chinese adults who use 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) to scan the whole body at Huashan Hospital from 2009 to 2013. BAT activity will be measured by PET/CT. Not only demographic data on sex, age, medication and medical history,but also data on body composition and physical examination will be collected for all subjects. Imaging date,outdoor temperature and fasting blood samples will be collected as well. In addition, the investigators will analyse the metabolic profiles in healthy adults with active BAT and their negative controls,such as lipid profiles,fasting glucose and insulin sensitivity, adipokines and other biochemical markers.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects with detectable brown adipose tissue
• Negative controls,consisting of one subject who underwent PET/CT scans at the same day but without detectable BAT

Exclusion criteria

• Younger than 18 years
• Pregnant women
• With implantable medical electronic instrument