The Increase Study. Effect of Incremental Versus Fixed Pump on Peak Oxygen Consumption in Heart Failure Patients Supported With a Continuous Flow Left Venticular Assist Device

Rigshospitalet

Status: Completed

Conditions: Heart Failure.

Treatments: Device: Incremental pump speed of CF-LVAD.

Study type: Interventional

Funder types: Other

Identifiers

NCT01698398

H-1-2012-092

Details and patient eligibility

About

The purpose of the study is to examine the relationship between working capacity (peak oxygen consumption) and pump speed of continuous flow left ventricular assist devices (CF-LVADs)in heart failure patients. The hypothesis is that it is possible to increase peak oxygen consumption by incrementally increasing CF-LVAD pumpspeed during exercise.

The study population will consist of severe heart failure patients with CF-LVADs treated at The Heart Centre of Copenhagen University Hospital Rigshospitalet.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• HeartMate II patients who underwent surgery and follow-up at The Heart Centre of Rigshospitalet.
• Heart failure in stable phase without the need for intravenous inotropic therapy.
• Ischemic and non-ischemic cardiomyopathy.

Exclusion criteria

• Severe aortic insufficiency.

Trial design

0 participants in 1 patient group

CF-LVAD pumpspeed.

Experimental group

Description:

Optimal pumpspeed setting of CF-LVAD during exercise on ergometric bicycle.

Treatment:

Device: Incremental pump speed of CF-LVAD.