The Incretin Effect in Patients With Gestational Diabetes Mellitus

Medical University of Lodz

Status: Completed

Conditions: Gestational Diabetes

Study type: Observational

Funder types: Other

Identifiers

NCT01307995

GDM-INK

Details and patient eligibility

About

The aim of this study is to evaluate the reduced incretin effect observed in patients with T2DM in relation to reversibility. The incretin effect will be measured by means of OGTT and iIVGTT in 12 women with GDM during pregnancy (third trimester), and again 2-3 months post partum. It is anticipated that the incretin effect in patients with GDM is reduced - like in patients with other forms of DM. The investigators estimate that approximately 90 % of the patients with GDM re-establish a NGT 2-3 months post partum. This particular group of patients provides a unique possibility for demonstrating the reversibility of the reduced incretin effect in relation to optimal glycaemic control.

Enrollment: 20 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age above 18 years old
• GDM diagnosed according to WHO guidelines (GDM group) or ruled out by OGTT 75g (Control group)

Exclusion criteria

• Previous diagnosis of DM
• Positive GAD-65-autoantibodies and/or positive islet cell autoantibodies (ICA)
• Affected biochemical liver parameters (ALAT > 2 times normal upper range)
• Affected biochemical kidney parameters (se-creatinine > 130 µM)
• Treatment with medicine interacting with insulin secretion (e.g. steroids)
• Treatment with medicine that can not be paused for 16 hours

Trial design

20 participants in 2 patient groups

GDM

Description:

Patients with Gestational Diabetes Mellitus found during pregnancy by means of 75g OGTT

NGT

Description:

Pregnant patients with normal glucose tolerance as observed in 75g OGTT