The Influence Factors of Ovarian Response in PCOS Patients With IVF-ET Treatment

Peking University

Status: Unknown

Conditions: Polycystic Ovary Syndrome

Treatments: Behavioral: Lifestyle Counseling

Study type: Interventional

Funder types: Other

Identifiers

NCT02331758

2014180

Details and patient eligibility

About

The purpose of this study is to explore the factors which affect ovarian response of PCOS patients with IVF-ET treatment, in order to provide predictive clinical index for the outcome of IVF-ET treatment in PCOS patients. After figuring out the controllable factors, researchers would be able to educate PCOS patients and improve the success rate while reducing the incidence of complications during the treatment at the same time.

Full description

Statistics of PCOS patients like age, BMI index and others would be collected. Through distributing questionnaires and query of past cases and collecting data recorded during the ovulation process like monitoring fluctuations in blood and ultrasonic monitoring results, researchers obtain the risk factors of the occurence of Ovarian Hyperstimulation Syndrome(OHSS) in IVF-ET treatment in PCOS patients and set up an OHSS prediction model, choose controllable factors in order to make up guidance and have intervention on patients with PCOS accordingly. The investigators expect this could improve the success rate of IVF-ET treatment in patients with PCOS, provide clues and assist to reduce the risk of the therapy.

Enrollment: 1,000 estimated patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of PCOS
• Long schedule time of Luteal phase
• Available to trace
• Normal Prolactin level with contraceptive treatment in recent 3 months

Exclusion criteria

• Unwilling to participate

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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1,000 participants in 2 patient groups

Lifestyle counseling

Experimental group

Description:

The investigators use several methods to educate patients of controllable factors like lifestyle counseling, and monitor the factors like BMI and other index until the statistics become normal.

Treatment:

Behavioral: Lifestyle Counseling

No treatment

No Intervention group

Description:

Patients without any intervention and still have abnormal factors like BMI, etc.