The Influence of Adjuvant Medical Treatment of Peritoneal Endometriosis on the Outcome of IVF. A Prospective Randomized Analysis.

AZ Jan Palfijn Gent

Status and phase: Completed; Phase 4

Conditions: Infertility; Endometriosis

Treatments: Drug: Zoladex

Study type: Interventional

Funder types: Other

Identifiers

NCT01682642

2012-000784-25

Details and patient eligibility

About

In this study of endometriosis patients we compare a common treatment of surgical therapy and medical treatment for 3 months (Zoladex) with patients receiving only surgical therapy. In both cases they immediately start In Vitro Fertilization (IVF) treatment.

Enrollment: 120 patients

Sex: Female

Ages: 18 to 38 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• laparoscopical vaporization of endometriosis
• 1,2, 3e IVF cycle
• endometriosis stage I and II
• younger than 38 years

Exclusion criteria

• endometriosis cysts
• uterine pathology
• endocrinological diseases and problems

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

Zoladex

Active Comparator group

Description:

After surgical vaporization of endometriosis patients are treated with Zoladex for 3 months.

Treatment:

Drug: Zoladex

vaporization only

No Intervention group

Description:

Surgical vaporization of the endometriosis is done and patients start IVF without additional treatment.