The Influence of AMH on Ovarian Responsiveness to Ovulation Induction With GnRH in Women With PCOS

Ain Shams Maternity Hospital

Status: Unknown

Conditions: Infertility

Treatments: Drug: Merional ®

Study type: Observational

Funder types: Other

Identifiers

NCT02673632

ASU2016

Details and patient eligibility

About

The investigator suggests that PCOS women with high AMH levels are resistant to ovarian stimulation and may need adjustment of the dose of gonadotrophin.

Full description

There is a correlation between high levels of AMH and the severity of PCOS. Excessive AMH may have a negative effect on the sensitivity of the resting follicles to gonadotropins.

This is an observational prospective study to investigate the impact of circulating AMH on gonadotrophin induction in women with PCOS.

Enrollment: 30 estimated patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women of age 18 - 35 years
• BMI 20 - 30 kg/m2
• Anovulatory infertility
• Diagnosis of PCOS based on Rotterdam consensus criteria (two of three criteria: Oligo/anovulation, hyperandrogenaemia and sonographic appearance of polycystic ovaries)

Exclusion criteria

• Women Above 35 years or under 18 years
• Women with BMI above 30 kg/m2 or under 20 kg/m2
• Normally ovulating women
• Patients with marked hyperandrogenaemia were screened for congenital adrenal hyperplasia (by measuring serum concentration of 17alpha hydroxyl-progesterone) or Patients with Cushing syndrome (by measuring urinary free cortisol)