The Influence of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Renal Function in Patients Undergoing Non-emergent Coronary Angiography

Soroka University Medical Center

Status: Completed

Conditions: Blood Pressure

Treatments: Drug: ACE/ARB stopped 24 hours before procedure and start immediately after; Drug: stop ace-i/arb 24 h before procedure and restarted 24 hours after the procedure

Study type: Interventional

Funder types: Other

Identifiers

NCT01071642

sor495209ctil

Details and patient eligibility

About

The aim of the current study is to evaluate prospectively whether concomitant administration of RAAS blockers (namely ACE-I and ARBs') influence the change in estimated GFR (eGFR) after administration of contrast media in patients undergoing non-emergent coronary angiography.

Enrollment: 100 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. Age>18 years
• 2. Subjects on chronic therapy with ACE-I and/or ARBs' (confirmed by electronic records in their medical file)
• 3. Subjects planned to undergo non-emergent coronary angiography.
• 4. Signed informed consent

Exclusion criteria

• 1. eGFR<30 ml/min at baseline
• 2. Chronic utilization of NSAIDS and Cox-2 selective inhibitors
• 3. Chronic treatment with mineralocorticosteroid receptor blocker
• 4. Systolic blood pressure<90 mmHg
• 5. Planned staged (repeated) procedure within 48 hours
• 6. Administration of contrast within 14 days prior to the enrollment
• 7. contraindication to stop ACE-I or ARB'S

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 3 patient groups

continue ace-i and arb's versus dicontinue

No Intervention group

group b

Active Comparator group

Treatment:

Drug: stop ace-i/arb 24 h before procedure and restarted 24 hours after the procedure

group c

Active Comparator group

Treatment:

Drug: ACE/ARB stopped 24 hours before procedure and start immediately after