The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy

University of Cologne

Status: Completed

Conditions: Trabeculectomy; Wound Healing; Glaucoma

Treatments: Procedure: Trabeculectomy

Study type: Observational

Funder types: Other

Identifiers

NCT01115218

MeVeTra-2009

Details and patient eligibility

About

The aim of the study is to investigate whether it is possible to predict the success of trabeculectomy in patients with glaucoma through the examination of mediators of wound healing in anterior chamber fluid. The success rate of trabeculectomy with mitomycin C in the literature is about 75%. This leads on the question why 25% of the patients received trabeculectomy are not sufficient treated and have not a long-term IOP reduction. Precisely this question is to be examined by the study.

Enrollment: 62 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with glaucoma with a trabeculectomy required
• 60 eyes of 60 patients, The ratio of female / male is not involved.
• Eye pressure under local therapy: 20mmHg and above (corrected with pachymetry table).
• age of at least 18 years

Exclusion criteria

• all patients not included in the group of inclusion criteria.
• less than 50yl anterior chamber fluid could be collected during the operation.

Trial design

62 participants in 1 patient group

Glaucoma patients

Treatment:

Procedure: Trabeculectomy