The Influence of Cancer Stem-cells on Risk of Relapse in Patients Harboring Adenocarcinoma and Squamous Cell Carcinoma of the Lung

Beatrice Aramini

Status: Completed

Conditions: Lung Cancer, Nonsmall Cell; CSC; Relapse/Recurrence

Treatments: Genetic: Exposure to lung cancer stem cells

Study type: Observational

Funder types: Other

Identifiers

NCT04634630

STEMCELL/1

Details and patient eligibility

About

The present study is a prospective cohort study. The aim is to assess the relationship between the presence of cancer stem-cells (CSC) and the risk of relapse in patients with early and locally advanced adenocarcinoma and squamous cell carcinoma of the lung

Enrollment: 35 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with stage I, II or IIIA adenocarcinoma of squamous cell carcinoma of the lung
• age between 18 and 85
• R0 resection
• availability of formalin-fixed, paraffin-embedded surgery specimen from the primary tumor
• availability of fresh surgical specimen for cytofluorimetric analysis

Exclusion criteria

• incomplete resection
• unknown tumor, node or metastasis status
• synchronous tumors
• previous lung cancer