The Influence of Collective Schemas on Individual Memory (MULTIBRAIN_2)

Institut National de la Santé Et de la Recherche Médicale, France

Status: Completed

Conditions: Episodic Memory

Treatments: Behavioral: Episodic memory task; Device: fMRI

Study type: Interventional

Funder types: Other

Identifiers

NCT02542800

C14-30

2014-A00650-47 (Registry Identifier)

Details and patient eligibility

About

Schemas describe mental structures storing recurrent and organized pattern of information. Schemas may have a strong influence on the process of storing and retrieving new information into memory. Previous approaches in the cognitive neuroscience of memory have entirely focused on the individual dimension of preexisting schemas. In the real world though, much of the researchers' experiences and knowledge are collective or shared. Such social-cultural frameworks stored in collective memory may also reshape and reconfigure the construction of individual memories. Attempting to ascertain the influence of collective schema on the neural substrates of individual memories using cutting-edge brain imaging methods represents the challenge that MULTIBRAIN2 seeks to tackle. To achieve this goal, the researchers will record brain activity during MRI scanning sessions in a group of 24 participants while they are performing an encoding followed by episodic memory retrieval tasks on pictures of the World War II Memorial of Caen. This study will seek to identify brain areas of the prefrontal cortex encoding the organization of knowledge in collective memory using multivariate analyses of brain activity patterns, and then to understand how such regions might modulate the recruitment of the hippocampus during episodic memory retrieval using analyses of effective connectivity. The organization of knowledge in collective memory is measured in parallel through 1) the analysis of French social memory of World War II using a corpus of thousand of television and radio shows from the National Institute of Audiovisual, and 2) an internet task measuring the organization of shared individual knowledge about World War II. Once collected, these data will help us to understand how collective schemas may shape the organization of individual memories.

Enrollment: 26 patients

Sex: All

Ages: 20 to 38 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy participants between 20 and 38 years old
• Affiliated to the French national health care system
• French native speaker
• Having not visited the Memorial of Caen for the past four years
• Right-handed
• At least 2 years of education after graduating from high school
• Body mass < 30kg/m2
• Signed written consent form

Exclusion criteria

• Pregnancy or intent to get pregnant
• Person deprived of their liberty
• Person hospitalized without consent
• Minor
• Protected adults or people unable to give informed consent
• Person subjected to an exclusion period related to another protocol
• History of neurological or psychiatric disorders or existence of traumatic brain injury with loss of consciousness for more than one hour
• History of cancer with the last 5 years, excluding squamous cell carcinomas
• Alcoholism, antecedents of chronic alcoholism or drugs abuse
• Severe psychiatric disorders (according to DSM V diagnostic criteria) or psychological troubles which could affect participant's judgment
• Use of medication that may interfere with cognitive or cerebral functioning
• Presence of visual or hearing troubles that may compromise participant's ability to participate in the study
• MRI Contraindications

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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26 participants in 1 patient group

Healthy participants

Experimental group

Treatment:

Device: fMRI

Behavioral: Episodic memory task