The Influence of Dietary Plant Sterols and Plant Stanols on Cholesterol and Plant Sterol Levels in Atheromatous Plaques

University of Helsinki

Status: Completed

Conditions: Atherosclerosis

Treatments: Dietary Supplement: Plant Stanol; Dietary Supplement: Plant Sterol

Study type: Interventional

Funder types: Other

Identifiers

NCT00737919

215953

Details and patient eligibility

About

This study aims to explore whether the increased supply of dietary plant sterols and plant stanols have any influence on serum levels of phytosterols and on consistency of carotid atheromatous plaques.

Full description

This is a double-blind randomized study. The study population will consist of 30 consecutive patients who will undergo an elective carotid endarterectomy due to a tight asymptomatic stenosis. The patients will be randomized into two groups consuming either plant sterol (2g/day) or plant stanol (2g/day) spreads for two to six weeks, until the operation. Serum lipids, lipoproteins and sterols will be analyzed at the randomization, before the operation and one month after the operation. The carotid arteries will be examined for their composition of sterols.

This study gives new information concerning the relationship between dietary consumption of plant sterols and stanols and the sterol composition of the carotid plaques.

Enrollment: 30 estimated patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Asymptomatic tight carotid plaques
• Age 40-80

Exclusion criteria

• No

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups

1

Active Comparator group

Description:

A group of subjects consuming daily 2 grams of plant stanols 4-6 weeks before the operation

Treatment:

Dietary Supplement: Plant Stanol

2

Active Comparator group

Description:

A group of patients consuming daily 2 grams of plant sterols 4-6 weeks before the operation

Treatment:

Dietary Supplement: Plant Sterol