The Influence of Endurance Sports Activity on the Oral Microbiota of Young Adults. (ORAMICAP)

Centre Hospitalier Universitaire de Nice

Status: Enrolling

Conditions: Microbial Colonization

Treatments: Other: salivar and gum sampling

Study type: Interventional

Funder types: Other

Identifiers

NCT05765422

22-PP-11

Details and patient eligibility

About

The oral cavity is an easily accessible anatomical site that accurately reflects the health of the individual. The mouth is considered an early indicator of biological aging, leading to the identification of oral biomarkers predictive of future alterations. Current data show that the oral health of high level athletes is globally altered with an increase in cariogenic indexes, an increased incidence of periodontitis, dental trauma and dry mouth syndromes. Few studies have focused on the oral microbiota compared to mouthguards used in rugby or boxing which seem to induce dysbiosis, a recent study shows an effect of ketogenic diet on bacterial changes in the mouth of endurance athletes. This project focuses on the impact of intensive sport practice on oral health and the identification of oral biomarkers associated with physical activity. The objective of this study is to investigate the impact of the amount of endurance sport practice on oral microbiota and oral health in young adults. the hypothesis is that a sedentary lifestyle and high-level sport induce depletion and/or changes in the oral microbiota compared to regular physical activity.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Be between 18 and 30 years old
• If practicing sports, it must be an endurance sport as main activity (cycling or running)

Exclusion criteria

• Practice more than 3 hours of swimming per week
• Have taken anti-inflammatory drugs, less than 48 hours before the study
• Have taken antibiotics and/or probiotics, less than 3 weeks before the study

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 3 patient groups

sedentary

Other group

Description:

Participant does not meet WHO's recommendations with the physical activity

Treatment:

Other: salivar and gum sampling

OMS recommandations

Other group

Description:

Participant does not meet WHO's recommendations (2.5-5 hours per week of moderate physical activity OR 1.25-2.5 hours per week of vigorous physical activity);

Treatment:

Other: salivar and gum sampling

More than the OMS recommandations

Other group

Description:

Participant is practicing physical activity more than the WHO recommendations

Treatment:

Other: salivar and gum sampling