The Influence of Exercise and Hydration to the Pharmacological Response to Inhaled Terbutalin and Salbutamol in Men

Vibeke Backer

Status and phase: Withdrawn; Phase 4

Conditions: Healthy

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT05749523

2013-000483-29

Details and patient eligibility

About

To investigate the effects of dehydration and exercise for the urine secretion of beta2-agonists.

Full description

No studies have examined the influence of factors such as exercise and dehydration on the pharmacokinetic profile of asthmatic drugs (beta2-agonists). Exercise may modify the metabolism and excretion of drugs, and sweat loss during exercise can result in dehydration, both affecting the urine concentration of the drug.

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• men
• aerobic capacity more than 50ml / min / kg
• more than 5h training pr week

Exclusion criteria

• smokers
• allergy for the medicine
• chronic diseases

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Double Blind

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0 participants in 1 patient group

Exercise

Other group

Description:

Exercise vs. non-exercise

Treatment:

Behavioral: Exercise