The Influence of Heart Rate Reduction Upon Central Arterial Pressure in Younger and Older Healthy Individuals

B

Bayside Health

Status and phase

Withdrawn
Phase 4

Conditions

Blood Pressure

Treatments

Drug: ivabradine
Drug: metoprolol
Drug: placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT01029223
141/07

Details and patient eligibility

About

The purpose of this study is to determine the effect of slowing heart rate upon both central and peripheral blood pressures using a medication called Ivabradine which slows heart rate without affecting heart contraction, and to compare the effects of ivabradine to a traditional blood pressure lowering medication called metoprolol (which is a beta-blocker).

Enrollment

42 estimated patients

Sex

Male

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: Aged 18 - 25 years OR Aged > 60 years Exclusion Criteria Chronic disease Unable to give informed consent Treated or untreated systemic arterial hypertension (SBP > 160 mmHg and/or DBP > 90 mmHg) Resting bradycardia (heart rate < 60 beats/minute) Pregnancy or active lactation

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Quadruple Blind

42 participants in 3 patient groups, including a placebo group

ivabradine
Experimental group
Treatment:
Drug: ivabradine
metoprolol
Experimental group
Treatment:
Drug: metoprolol
placebo
Placebo Comparator group
Treatment:
Drug: placebo

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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