The Influence of Menopausal Status on Myocardial Stiffness and Exercise Capacity Among Female Masters Endurance Athletes.

Mayo Clinic

Status

Completed

Conditions

Myocardial Stiffness

Treatments

Diagnostic Test: Cardiovascular Magnetic Imaging (cMRI)

Diagnostic Test: Stress Echocardiogram

Diagnostic Test: Cardiac Magnetic Resonance Elastography (cMRE)

Study type

Observational

Funder types

Other

Identifiers

NCT06475768

24-001460

Details and patient eligibility

About

The purpose of this research is to study postmenopausal female masters athletes to see if they will show greater myocardial stiffness and reduced exercise capacity than premenopausal females and similarly aged male masters athletes.

Enrollment

48 patients

Sex

All

Ages

40 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Longstanding history of competitive endurance athletic performance defined as >15 years of continuous athletic training for at least 7 hours per week and ongoing engagement in competitive events.

Exclusion criteria

A current or prior diagnosis of cardiovascular disease as defined by the presence of structural heart disease, heart failure, symptomatic coronary artery disease, more than moderate valve disease or prior valve surgery,
Current or recent pregnancy within 1 year
Positive pregnancy test (study visit 1)
Concurrent or use within 1 year of oral contraceptives or hormone replacement therapy,
Unable to undergo a cMRI (Please refer standard clinical contraindications for MRI)