The Influence of NPPA/NPPB Haplotype on Natriuretic Peptide Plasma Levels

Insel Gruppe AG, University Hospital Bern

Status: Completed

Conditions: Surgical Procedure, Operative; Anesthesia

Study type: Observational

Funder types: Other

Identifiers

NCT04327258

041/09e

Details and patient eligibility

About

Crosssectional study to analyse the genetic influence on levels of cardiac biomarkers (BNP, NT-proBNP).

Full description

Background

Natriuretic peptides play an important role in risk stratification and management of patients undergoing non-cardiac surgery. However, due to genetic variability, the levels of these biomarkers may differ in individual patients with cardiac derangement. In the preoperative setting, genetic contribution to natriuretic peptide plasma level variability has not yet been determined.

Objective

The aim of this study is to assess genetic contribution to NP plasma level variability in a Swiss cohort.

Methods

Cross-sectional association study in a cohort of non-cardiac surgery patients.

This study is a Subproject of a prospective cohort study registered under the ID 041/09.

Enrollment: 437 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• 18 years and older
• Written informed consent
• Scheduled surgery

Exclusion Criteria

• No informed consent
• Cognitive impairment

Trial design

437 participants in 1 patient group

All patients

Description:

Patients undergoing elective surgery with anesthesia