The Influence of Omega-3 Fatty Acid on the Violence of Schizophrenia Patient and the Possible Mechanism

Shanghai Mental Health Center

Status: Unknown

Conditions: Schizophrenia

Treatments: Device: positron emission tomography (PET); Biological: placebo; Biological: omega-3 fatty acid

Study type: Interventional

Funder types: Other

Identifiers

NCT02552758

2014-25

Details and patient eligibility

About

Investigators plan to explore whether Omega-3 fatty acid have effect on the violent behavior of the schizophrenia patients. Investigators will use PET to explore the influence on serotonin function of the brain to understand the mechanism of how Omega-3 fatty acid works. This study will enroll 100 patients of schizophrenia with violent behavior.Participants will be split into two groups randomly. In one group, participants will receive one pill of placebo per day, and in the other, participants will have one pill of 900mg Omega-3 fatty acid per day. This intervention will last 3 months.At week 0, week 4, week 8 and week 12, some scales will be evaluated. Meanwhile, the density of eicosapentaenoic acid(EPA),docosahexaenoic acid (DHA),noradrenalin(NE), dopamine(DA) and serotonin(5-HT) in blood will be tested.At week 0 and week 12, 10 patients of each group will be randomly selected to have the exam of PET.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• the sore of MOAS scale >=4 more than 2 violent behavior in recent 6 months by self repot

Exclusion criteria

• serious diseases,such as cardiovascular diseases,nervous system disease. allergy to fish oil

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups, including a placebo group

Omega-3 fatty acid

Experimental group

Description:

omega-3 fatty acid

Treatment:

Biological: omega-3 fatty acid

Device: positron emission tomography (PET)

placebo

Placebo Comparator group

Description:

placebo

Treatment:

Device: positron emission tomography (PET)

Biological: placebo