The Influence of Peripheral Nerve Blocks in Patients Undergoing Limb Orthopedic Surgery

Kaohsiung Medical University

Status: Completed

Conditions: Change; Circulatory; Surgical Injury; Pain, Postoperative

Treatments: Procedure: 0.25% bupivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT03913650

KMUH-IRB-F(I)-20170007

Details and patient eligibility

About

To investigate pre-op peripheral nerve block in reducing peri-op IL-6 level and post-op pain

Full description

In orthopedic surgery, peripheral nerve block can be used as an anesthesia adjuvant prior to surgery. In this study, we hypothesized that peripheral nerve blocks may alleviate inflammatory response and reduce the analgesics requirement. Sixty patients undergoing limb orthopedic surgery will be enrolled. Peripheral nerve block was injected with 0.25% bupivacaine under ultrasound guidance. 30 patients (Study group) underwent surgery with nerve blocks and another 30 patients (Control group) underwent surgery with morphine. The anesthetic protocol was standardized for both groups by experienced anesthesiologists. Surgical stress was assessed by blood pressure fluctuation and proinflammatory cytokine. Pain intensity was measured by numeric rating scale (NRS) score for 24 hours

Enrollment: 60 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of limb fracture
• must receiving orthopedic surgery

Exclusion criteria

• With the comorbidity of chronic heart, lung, liver and renal disease, Chronic alcoholism, Allergy to bupivacaine

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Nerve block(+)

Active Comparator group

Description:

patient accept nerve block for post-op pain control

Treatment:

Procedure: 0.25% bupivacaine

Morphine

Sham Comparator group

Description:

patient received morphine for post-op pain control

Treatment:

Procedure: 0.25% bupivacaine