The Influence of Pressure Pain on [11C]Diprenorphine Binding Potentials

Mass General Brigham

Status: Completed

Conditions: Healthy Controls

Treatments: Radiation: PET imaging

Study type: Interventional

Funder types: Other

Identifiers

NCT01546155

2011P0022171

Details and patient eligibility

About

Healthy volunteers aged 21 to 50 are needed for a research study investigating whether pain will alter the binding properties of ([11C]diprenorphine), a molecule that can be used during brain imaging. Positron Emission Tomography (PET) and functional Magnetic Resonance (fMRI) imaging will be used in this study.

Enrollment: 11 patients

Sex: All

Ages: 21 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male and female adults, 21 to 50 years of age
• No contraindications to fMRI and PET scanning
• Within 15% of ideal body mass index (BMI)

Exclusion criteria

• Current significant medical, neurological, or psychiatric illness as assessed by the Physician Investigators
• Women who are pregnant or breast feeding, have gone through menopause, and/or have irregular menstrual cycles
• Claustrophobia
• History of head trauma
• Instability of responses to experimental pain (See Study Procedure Section Part II)
• History of asthma
• Use of psychotropic drugs or hormone treatments (including hormonal birth control) within one year of date of consent
• History of smoking
• Routine exercise in excess of one hour per day and/or three times per week
• Non-fluent English speaker

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

11 participants in 1 patient group

healthy controls

Experimental group

Treatment:

Radiation: PET imaging