The Influence of Probiotics on Vancomycin-Resistant Enterococcus

Oregon Health & Science University (OHSU)

Status: Terminated

Conditions: GI Colonization of Vancomycin-resistant Enterococcus

Treatments: Dietary Supplement: yogurt; Dietary Supplement: probiotics

Study type: Interventional

Funder types: Other

Identifiers

NCT00591474

IRB3848

Details and patient eligibility

About

Drinking probiotics in a the form of a yogurt drink will restore normal gastrointestinal (GI) bacteria in patients whose colon are colonized with vancomycin-resistant enterococcus (VRE).

Enrollment: 8 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• VRE positive patients with GI colonization

Exclusion criteria

• Age less than 18 years
• Patients who have had a bone marrow transplant
• Extreme short bowel patients (less than 100 cm small bowel remaining)
• Patients with active VRE infection but no GI colonization
• Patients unable to eat and have no feeding access
• Patients who do not have a power of attorney to give consent if they are unable to

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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8 participants in 2 patient groups, including a placebo group

1

Experimental group

Description:

VRE positive patients

Treatment:

Dietary Supplement: probiotics

2

Placebo Comparator group

Description:

VRE positive patients

Treatment:

Dietary Supplement: yogurt