The Influence of Prone Position for Spinal Surgery on Visual Acuity

University Hospital Hradec Kralove

Status: Not yet enrolling

Conditions: Vision; Disorder, Loss

Treatments: Procedure: Propofol Group; Procedure: Desflurane Group

Study type: Interventional

Funder types: Other

Identifiers

NCT03644641

UHospital Hradec Kral

Details and patient eligibility

About

This study investigated the effect of desflurane and propofol anesthesia on visual acuity in patients in prone position for spinal surgery. Many trials have investigated the effects of different anesthetic agents on intraocular pressure, propofol may reduce intraocular pressure more than other intravenous anesthetics.

Full description

Perioperative increase in intraocular pressure can be caused by prone positioning. In addition to surgical factors, patients with glaucoma, uncontrolled hypertension, arthrosclerosis, and morbid obesity are at risk for potentially damaging optic nerve and loss of optic nerve function. Some studies found that intraocular pressure values were significantly lower in patients undergoing propofol total intravenous anesthesia than in patients undergoing desflurane anesthesia during intraoperative positional changes. Pronounced vasodilatation caused by desflurane might produced hyperaemia with higher intraocular pressure. Hemodynamic response to prone position measured by near-infrared spectroscopy (NIRS) on the prefrontal cortex could determine changes caused by prone position.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Glasgow Coma scale 15
• American Society of Anesthesiologists (ASA) Physical Status Classification System I-III
• spinal surgery in duration less than 3 hours
• sinus rhythm

Exclusion criteria

• postoperative artificial ventilation
• serious neurological disease
• lung disease with hypercapnia
• propofol allergy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups

Desflurane Group

Experimental group

Description:

Induction and anesthesia will be held by using desflurane

Treatment:

Procedure: Desflurane Group

Propofol Group

Experimental group

Description:

Induction and anesthesia will be held by using target-control anesthesia with propofol

Treatment:

Procedure: Propofol Group