The Influence of Remote Ischemic Preconditioning on Acute Kidney Injury After Cardiac Surgery

Robert Kramer, MD

Status and phase: Completed; Phase 1

Conditions: Acute Kidney Insufficiency; Acute Kidney Injury; Acute Renal Insufficiency; Ischemic Preconditioning

Treatments: Procedure: Remote Ischemic Preconditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT00821522

3401

Details and patient eligibility

About

Acute kidney injury is associated with cardiopulmonary bypass during heart surgery and its pathogenesis is similar to that of ischemia-reperfusion injury. Remote ischemic preconditioning attenuates myocardial ischemia-reperfusion injury in patients undergoing coronary bypass surgery. The investigators hypothesize that such preconditioning reduces the incidence of acute kidney injury associated with cardiopulmonary bypass.

Enrollment: 120 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient undergoing heart surgery on cardiopulmonary bypass.

Exclusion criteria

• Known peripheral vascular disease of the lower extremities associated with active skin necrosis or infection.
• End-stage renal disease.
• Inability to give informed consent.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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120 participants in 2 patient groups

Preconditioning

Active Comparator group

Treatment:

Procedure: Remote Ischemic Preconditioning

Control

No Intervention group

Description:

Standard clinical management during cardiac surgery.