The Influence of Sedation for Endoscopy on Cognitive Function

Shanghai Jiao Tong University School of Medicine

Status: Terminated

Conditions: Cognition Disorders; Esophagogastroduodenoscopy; Deep Sedation

Treatments: Device: endoscopy; Drug: Propofol

Study type: Observational

Funder types: Other

Identifiers

NCT04168294

rjyyxhk2017001

Details and patient eligibility

About

It is commonly recommended that patients should refrain from driving for 24 hours after sedation for endoscopy，however，this recommendation has been queried recently．To investigate the effect of sedation on early postoperative cognitive function in patients undergoing endoscopy.

Full description

One hundred adult patients undergoing sedative esophagogastroduodenoscopy ( EGD) were randomly recruited，and another 100 adult patients undergoing conventional（without sedation） EGD were served as controls． All patients had an education level more than 9 years． Cognitive function was assessed by Montreal Cognitive Assessment（MoCA）1 week before EGD exam, 10 mins before propofol sedation or the beginning of endoscopic procedure, 30mins after EGD exam, and 2 week after exam.

Enrollment: 200 patients

Sex: All

Ages: 20 to 64 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. The scores of MMSE are more than 26.
2. The AHA grade I and II.

Exclusion criteria

1. The AHA grade III, IV or V.
2. binge drinking.
3. Take sedatives, sleeping agents and some drug which may affect the study in a month.
4. Psychiatric disorders.
5. The dysfunction of heart, lung, liver and kidney.

Trial design

200 participants in 2 patient groups

sedation group

Description:

Patients undergo sedative esophagogastroduodenoscopy (EGD) and are intravenous injected propofol in bolus

Treatment:

Drug: Propofol

Device: endoscopy

control group

Description:

patients undergo conventional EGD

Treatment:

Device: endoscopy