The Influence of Sweet Substrates on Hunger, Gastrointestinal Hormones and the Migrating Motor Complex

Universitaire Ziekenhuizen KU Leuven

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: 25g fructose; Dietary Supplement: 50g glucose; Dietary Supplement: 220mg acesulfame-K; Dietary Supplement: 250mL tap water

Study type: Interventional

Funder types: Other

Identifiers

NCT02891525

GIMotilitySweetTaste

Details and patient eligibility

About

In this study, the investigators aimed at evaluating the role of sweet taste receptors in the gastrointestinal tract (GIT). Intragastric administration of glucose, fructose or acesulfame-K were compared with placebo administration for their effects on gastrointestinal motility, gut hormone release (motilin, ghrelin, glucagon-like peptide-1 (GLP-1) and insulin) and hunger feelings.

Enrollment: 12 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI<30 kg/m² for the lean volunteers
• Female or male subjects aged 18 to 60
• Subject is capable and willing to give informed consent
• Female volunteers of child bearing potential must use oral, injected or implanted hormonal methods of contraception

Exclusion criteria

• Female volunteer is pregnant or breastfeeding
• GI diseases, major abdominal surgery
• Volunteers that have food allergies, especially fructose intolerance
• Major psychiatric illnesses
• Volunteers that use drugs affecting the GI tract or the central nervous system
• Volunteers suffering from an endocrine disease such as diabetes, Cushing's disease, Addison's disease, hypothalamic tumor
• Volunteers that have undergone surgical procedure for weight loss

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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12 participants in 4 patient groups, including a placebo group

50g glucose intragastric

Active Comparator group

Description:

50g glucose dissolved in 250mL tap water given via nasogastric tube

Treatment:

Dietary Supplement: 50g glucose

25g fructose intragastric

Active Comparator group

Description:

25g glucose dissolved in 250mL tap water given via nasogastric tube

Treatment:

Dietary Supplement: 25g fructose

220mg acesulfame-K intragastric

Active Comparator group

Description:

220mg acesulfame-K dissolved in 250mL tap water given via nasogastric tube

Treatment:

Dietary Supplement: 220mg acesulfame-K

250mL tap water intragastric

Placebo Comparator group

Description:

250mL tap water given via nasogastric tube

Treatment:

Dietary Supplement: 250mL tap water