the Influence of Tidal Volume to Lung Strain

Southeast University

Status: Unknown

Conditions: Critically Ill; Acute Respiratory Distress Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT01864668

20130519

Details and patient eligibility

About

Measure the lung strain in different tidal volume in ADRS patients to find the relationship between tidal volume and lung strain and find the most suitable tidal volume for each patient.

Full description

Purpose:Find the relationship between tidal volume and lung strain in ARDS patients.Then find the most suitable tidal volume for each patient according to the dividing value.

Methods:Measure the lung strain in the tidal volume of 6mL/kg,8mL/kg,10mL/kg and 12mL/kg in each ARDS patient.

Hypothesis:With the increase of the tidal volume,the lung strain develops.In the patient with larger lung compliance,the strain of the group of conventional tidal volume is less than 0.27 and there is no obvious difference between the group of small tidal volume.

Enrollment: 25 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age:18-85,gender is not limited
2. Needing Invasive ventilation
3. Fit the definition of ARDS in 2012 "Berlin Definition"
4. Sign the paper of informed consent

Exclusion criteria

1. pregnancy and at the end stage of tumour
2. the COPD patients
3. less than 24h of mechanical ventilation
4. more than 5 days of mechanical ventilation
5. FiO2>80%
6. presence of air leaks
7. organ dysfunction and hemodynamic instability
8. including in other research