The Influence of Type of Anesthesia on Postoperative Pain

Seoul National University

Status: Active, not recruiting

Conditions: Colo-rectal Cancer; Anesthesia

Treatments: Drug: Sevoflurane; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT04239794

TIVA-IA-Pain

Details and patient eligibility

About

The investigators designed a multi-center prospective randomized controlled trial to study the influence of the type of anesthesia on postoperative pain after laparoscopic colorectal cancer surgery. Half of the participants will be anesthetized with propofol and remifentanil, while the other half will be anesthetized with sevoflurane and remifentanil during the surgery. The investigators will measure opioid consumption and pain score in the acute postoperative phase.

Full description

Previous studies showed that patients receiving total intravenous anesthesia (TIVA) with propofol are associated with less postoperative pain and less opioid consumption compared with inhalation anesthesia. However, some studies showed conflicting results. In colorectal surgery, there are only retrospective studies that showed the analgesic effect of TIVA and inhalation anesthesia. The investigators designed a multi-center prospective randomized controlled trial and hypothesized that TIVA with propofol would be associated with reduced postoperative opioid consumption and less postoperative pain compared with sevoflurane in laparoscopic colorectal cancer surgery.

Enrollment: 468 patients

Sex: All

Ages: 19 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patient scheduled for elective laparoscopic colorectal cancer surgery

Exclusion criteria

• Pregnant
• Conversion from laparoscopic to open surgery
• Allergy to anesthetics and analgesics
• Previous abdominal surgery
• Chronic pain
• Chronic analgesic usage

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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468 participants in 2 patient groups

Inhalation anesthesia

Active Comparator group

Description:

Patients are anesthetized with sevoflurane and remifentanil infusion for maintenance of anesthesia during the surgery

Treatment:

Drug: Sevoflurane

Total intravenous anesthesia

Experimental group

Description:

Patients are anesthetized with target-controlled intravenous infusion of propofol and remifentanil infusion for maintenance of anesthesia during the surgery

Treatment:

Drug: Propofol