The Influence of Warm Bupivacaine on Supraclavicular Plexus Block Characteristics

Mansoura University

Status: Completed

Conditions: Surgery to the Distal One Third of the Upper Limb

Treatments: Drug: Bupivacaine at operating room temperature (23°c); Drug: Warm bupivacaine at (37°c)

Study type: Interventional

Funder types: Other

Identifiers

NCT03265886

MFM-IRB, MS/17.05.143

Details and patient eligibility

About

Despite PH adjustment of local anesthetic solution improves the quality of the block in all respects with special advantage of early onset of sensory and motor block, adequate level of analgesia, and prolongation of duration of block, the effect of warmed bupivacaine should have the same effect which have not been evaluated on supraclavicular plexus block for upper limb surgery.

The warmed bupivacaine used in supraclavicular plexus block may reduce sensory and motor block onset and prolong the duration of analgesia when compared to bupivacaine at operating room temperature.

Full description

The aim of this study is to compare the effect of warm bupivacaine 0.5% at 37◦C versus bupivacaine 0.5% at operating room temperature at 23◦C on ultrasound-guided supraclavicular plexus block characteristics as regard sensory block onset time, motor block onset time, duration of sensory and motor block , effective duration of analgesia, total analgesics requirement, complications and side effects.

Enrollment: 90 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists physical class I or II

Exclusion criteria

• Patient refusal.
• Pregnancy
• Neuromuscular diseases (as myopathies, myasthenia gravies...)
• Hematological diseases
• Bleeding disorders
• Coagulation abnormality.
• Psychiatric diseases.
• Local skin infection
• Sepsis at site of the block.
• Known intolerance to the study drugs.
• Body Mass Index > 40 Kg/m2.
• Bilateral upper limb injury to be performed at the same procedure.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 2 patient groups

Warm bupivacaine at (37°c)

Experimental group

Description:

Warmed bupivacaine at body temperature will be administered

Treatment:

Drug: Warm bupivacaine at (37°c)

Bupivacaine at operating room temperature (23°c)

Active Comparator group

Description:

Bupivacaine at temperature of 23°C will be administered

Treatment:

Drug: Bupivacaine at operating room temperature (23°c)