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The Influence of Water and Salt Intake on Copeptin Levels During Moderate Alcohol Consumption

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University Hospital Basel

Status

Completed

Conditions

Alcohol Drinking

Treatments

Other: Water
Other: Beer 8.5%o and stock
Other: Beer 8.5%o and water
Other: Beer 5%o

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

The main interest of this study is to investigate the influence of moderate alcohol consumption (beer) on salt-water homeostasis. Therefore, 10 healthy volunteers will participate in 4 Intervention:

  • Beer alone
  • Beer and water
  • Beer and salt (stock/bouillon)
  • Water alone During the study day, copeptin, sodium, osmolality and urinary sodium/osmolality will be measured at 6 timepoints.

Enrollment

10 patients

Sex

Male

Ages

20 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy males

Exclusion criteria

  • Any acute or chronic illness
  • History of alcohol dependency
  • Alcohol consumption >2 units/day
  • Active nicotine abuse
  • Gluten intolerance
  • Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, etc. of the participant
  • Participation in another study with investigational drug within the 30 days preceding and during the present study
  • Enrolment of the investigator, his/her family members, employees and other dependent persons
  • Epileptic seizures within the last year
  • BMI <18.5 or ≥25.9kg/m2

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

10 participants in 4 patient groups, including a placebo group

Beer alone
Experimental group
Description:
Consumption of beer (correlated for weight to reach a blood alcohol concentration of 0.8) during 1 hour. Continues measurement of sodium, osmolality, copeptin, urinary sodium, urinary osmolality over 12 hours.
Treatment:
Other: Beer 5%o
Beer and water
Active Comparator group
Description:
Consumption of beer and additional water (correlated for weight to reach a blood alcohol concentration of 0.8, 1/3 of water, 2/3 of beer) during 1 hour. Continues measurement of sodium, osmolality, copeptin, urinary sodium, urinary osmolality over 12 hours.
Treatment:
Other: Beer 8.5%o and water
Beer and stock
Active Comparator group
Description:
Consumption of beer and additional stock(correlated for weight to reach a blood alcohol concentration of 0.8, 1/3 of stock, 2/3 of beer) during 1 hour. Continues measurement of sodium, osmolality, copeptin, urinary sodium, urinary osmolality over 12 hours.
Treatment:
Other: Beer 8.5%o and stock
Water alone
Placebo Comparator group
Description:
Consumption of water alone (correlated for weight to reach a blood alcohol concentration of 0.8, 1/3 of stock, 2/3 of beer) during 1 hour. Continues measurement of sodium, osmolality, copeptin, urinary sodium, urinary osmolality over 12 hours.
Treatment:
Other: Water

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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