The Interaction Between Appetite Hormones

University of Copenhagen

Status: Completed

Conditions: Obesity

Treatments: Dietary Supplement: low calorie diet; Other: GLP-1

Study type: Interventional

Funder types: Other

Identifiers

NCT02094183

H-4-2010-134

Details and patient eligibility

About

Glucagon Like Peptide (GLP) -1 affects metabolic response corrected for weight change

Full description

Many obese people have had several successful weight losses, however very few can maintain the weight loss over a longer period (e.g. one year) Therefore, we want to investigate the metabolic response and the importance for maintenance of weight loss in obese people, who lost at least 7, 5 % body weight by low calorie diet followed by 52 weeks of diet weight maintenance with or without supplement of GLP-1.

Enrollment: 58 patients

Sex: All

Ages: 18 to 64 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI > 30 and < 40 (kg/m2)
• Healthy

Exclusion criteria

• Other known illness
• Medicine that affects glucose- and lipid metabolism, appetite or food intake
• Pregnancy
• Breast feeding

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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58 participants in 2 patient groups

GLP-1

Experimental group

Description:

GLP-1 and low calorie diet

Treatment:

Dietary Supplement: low calorie diet

Other: GLP-1

Control

Experimental group

Description:

low calorie diet

Treatment:

Dietary Supplement: low calorie diet