The Interaction of Body Composition, Sex Hormones and Exercise in Men (AHA-NWO)

Oklahoma State University

Status: Enrolling

Conditions: Normal-weight Obesity

Treatments: Behavioral: Resistance Exercise Training; Behavioral: Aerobic Exercise Training

Study type: Interventional

Funder types: Other

Identifiers

NCT06970457

IRB-24-542

Details and patient eligibility

About

The overall objective of this project is to advance understanding of the causes of normal weight obesity (NWO) in men, namely the hormone profile and related potential mediating mechanisms, and the efficacy of different modes of exercise to restore body composition and cardiometabolic health in this population.

Enrollment: 96 estimated patients

Sex: Male

Ages: 18 to 79 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Biological male
• BMI 18.5 - 24.9 kg/m2 or >/= 30 kg/m2
• Body fat <20% or >/= 25%
• Ability and willingness to engage in an exercise training regimen

Exclusion criteria

• Presence of a chronic health condition, or regular use of associate prescribed medications, that would substantially impact study variables
• Excessive alcohol use or use of tobacco products, vape products, or illicit drugs
• Presence of an electrical implant, such as a pacemaker

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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96 participants in 2 patient groups

Resistance Exercise Training

Experimental group

Description:

12-weeks of progressive and individualized resistance exercise training

Treatment:

Behavioral: Aerobic Exercise Training

Behavioral: Resistance Exercise Training

Aerobic Exercise Training

Active Comparator group

Description:

12-weeks of progressive and individualized aerobic exercise training

Treatment:

Behavioral: Aerobic Exercise Training

Behavioral: Resistance Exercise Training