The Interaction of Flavor With Nicotine Form in Adult Smokers

Yale University

Status and phase: Completed; Phase 1

Conditions: Nicotine Dependence

Treatments: Drug: Nicotine form; Other: E-cigarette experimental flavor

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT04262817

2U54DA036151-06 (U.S. NIH Grant/Contract)

2000025687

1K01DA051882-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This study seeks to elucidate the impact of e-cigarette flavor on subjective effects and nicotine exposure from e-cigarettes containing different forms of nicotine.

Enrollment: 20 patients

Sex: All

Ages: 21+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• At least 21 years old, able to read and write, use of combustible

Exclusion criteria

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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20 participants in 2 patient groups

E-cigarette flavor

Experimental group

Description:

In this arm, participants will receive two experimental e-cigarette flavors

Treatment:

Drug: Nicotine form

Other: E-cigarette experimental flavor

E-cigarette nicotine form

Experimental group

Description:

In this arm, participants will receive two forms of nicotine in an e-cigarette

Treatment:

Drug: Nicotine form

Other: E-cigarette experimental flavor