The Joint Effect of Air Pollution and Exercise on Cognitive Function

Tsinghua University

Status: Completed

Conditions: Health Promotion; Air Pollution; Cognition; Exercise

Treatments: Behavioral: Air purification; Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT04830059

THU2021

Details and patient eligibility

About

A double-blind randomized controlled trial design is used in this study. A mixed design of 2 (pollution reduction group vs. no pollution reduction group) × 3 (high intensity intermittent exercise [HIIT], moderate intensity of aerobic exercise [MICT] and control group [CONT]) is used. 93 subjects recruited by advertising will be randomly divided into 6 groups: high intensity exercise group (pollution reduction vs no pollution reduction), moderate intensity aerobic exercise group (pollution reduction vs no pollution reduction) and Stretching group (Control) (pollution reduction vs no pollution reduction).

Full description

Environmental intervention program In the pollution reduction groups, the air purification system is used 2 hours before the subjects entered the room to minimize the indoor PM2.5 and PM10.

Exercise intervention program including HIIT, MICT and Stretching (Control) group :

The VO2max of all subjects are measured one week before the experiment. HIIT program: 20 minutes exercise of HIIT (1min of 100% VO2max and 1min of 50% VO2max alternately) and 10 minutes of warm-up and relaxation.

MICT program: 20 minutes exercise of 70-75% VO2max and 10 minutes of warm-up and relaxation.

Stretching control group: 30 minutes of stretching, posture adjustment and rehabilitation courses taught by professional therapists.

Enrollment: 93 patients

Sex: All

Ages: 20 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• No regular exercise in the past six months;
• Healthy people without history of disease;
• Aged between 20 and 30 years old.

Exclusion criteria

• Professional athletes;
• Regular exercise in the past six months;
• People who are injured or have a history of disease in the past six months;
• People who have a history of taking medicine in the past six months.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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93 participants in 6 patient groups

High intensity intermittent training

Experimental group

Description:

HIIT exercise program: 20 minutes HIIT exercise (1min 100% VO2max and 1min 50% VO2max alternately), and warm-up and relaxation before and after exercise for 10 minutes.

Treatment:

Behavioral: Exercise

HIIT with pollution reduction

Experimental group

Description:

HIIT program: 20 minutes HIIT exercise (1min 100% VO2max and 1min 50% VO2max alternately), and warm-up and relaxation before and after exercise for 10 minutes; Environmental pollution intervention program: air purification system is used order to reduce the PM2.5 and PM10.

Treatment:

Behavioral: Exercise

Behavioral: Air purification

Moderate intensity continuous training

Experimental group

Description:

MICT program: 20 minutes of 70-75% VO2max exercise and 10 minutes of warm-up and relaxation before and after exercise.

Treatment:

Behavioral: Exercise

MICT with pollution reduction

Experimental group

Description:

MICT program: 20 minutes of 70-75% VO2max exercise and 10 minutes of warm-up and relaxation before and after exercise; Environmental pollution intervention program: air purification system is used order to reduce the PM2.5 and PM10.

Treatment:

Behavioral: Exercise

Behavioral: Air purification

Stretch control group

Experimental group

Description:

Stretching control group: 30 minutes stretching, posture adjustment and rehabilitation courses is taught by professional therapist.

Treatment:

Behavioral: Exercise

Control with pollution reduction

Experimental group

Description:

Stretching control group: 30 minutes stretching, posture adjustment and rehabilitation courses is taught by professional therapist. Environmental pollution intervention program: air purification system is used order to reduce the PM2.5 and PM10.

Treatment:

Behavioral: Exercise

Behavioral: Air purification