The Learning and Memory of the Experience of Pain

Mass General Brigham

Status: Completed

Conditions: Pain

Treatments: Behavioral: Learning and Memory of Pain

Study type: Interventional

Funder types: Other

Identifiers

NCT01731314

2012P002386

Details and patient eligibility

About

This study investigates the learning and memory of pain.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Male and female healthy volunteers.
2. 18-65 years of age.
3. Right-handed.
4. Fluency in English. Ability to read and understand English; English can be a second language provided that the participant feels that he/she is able to understand all the questions used in the assessment measures.

Exclusion criteria

1. Any previous experience with conditioned analgesia/hyperalgesia paradigms.
2. Presence of any illness or medication use that is judged to interfere with the trial. For example: psychiatric disorder according to the DSM-IV manual, medication that can influence cognition or emotional processing, i.e. sleep medication, antidepressants, anti-convulsants or opioids.
3. Unwillingness to receive brief pain stimulation administered by a heat probe on the hand.
4. Instability of responses to experimental heat pain
5. Any contraindications to fMRI scanning for subjects in Experiment 2 (including metal implants, claustrophobia, history of head trauma, and pregnancy).
6. Peripheral neuropathy.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind