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The Link Between Mental Imagery and the Reduction of Fear in Imaginal Extinction

U

Uppsala University

Status

Completed

Conditions

Healthy Subjects

Treatments

Behavioral: Reinstatement
Behavioral: Imaginal extinction
Behavioral: Fear acquisition

Study type

Interventional

Funder types

Other

Identifiers

NCT03989518
2019-00524

Details and patient eligibility

About

Imaginal exposure is a widely used psychological treatment technique. Imaginal extinction is an experimental analogue of imaginal exposure, that allows the study of this treatment technique under controlled circumstances (Agren, Björkstrand, & Fredrikson, 2017). During imaginal extinction, experimentally induced fear is diminished through repeated exposure to mental imagery of the feared (conditioned) stimulus. However, it is not known to what extent fear reduction depends on the mental imagery produced during this procedure. A better understanding of the mechanisms driving the effects of imaginal exposure and the factors moderating fear reduction could have significant clinical utility, by suggesting mechanistically informed ways to improve this treatment.

Full description

The study takes part over three consecutive days, with fear conditioning to visual stimuli on day 1, imaginal extinction on day 2, and a fear reinstatement procedure, again to visual stimuli, on day 3. Skin conductance is used to measure fear responses.

Participants' are randomized to receive conditioning, extinction and reinstatement with either complex or simple stimuli. During imaginal extinction, imagery of each experimental stimulus is prompted through different verbal instructions.

Enrollment

60 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age 18 or over

Fluent in Swedish

Willing and able to provide informed consent and complete study procedures

Exclusion criteria

Current psychiatric disorder

Use of psychotropic medication within 6 months prior to study start

Receiving psychological treatment within 6 months prior to study start

Current neurological condition

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

60 participants in 2 patient groups

Simple stimuli
Experimental group
Description:
Two perceptually simple stimuli are used during all experimental phases (geometrical figures).
Treatment:
Behavioral: Reinstatement
Behavioral: Imaginal extinction
Behavioral: Fear acquisition
Complex stimuli
Experimental group
Description:
Two complex stimuli are used in all experimental phases. Stimuli consist of photographs of real objects of the same size and shape as the simple stimuli, but include perceptually more complex patterns, details and colors.
Treatment:
Behavioral: Reinstatement
Behavioral: Imaginal extinction
Behavioral: Fear acquisition

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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