The Link Between Periodontitis, Smoking and Oral Cancer

Cairo University (CU)

Status: Not yet enrolling

Conditions: Chronic Periodontitis; Oral Cancer

Treatments: Diagnostic Test: periodontal examination; Diagnostic Test: biopsy for oral cancer

Study type: Observational

Funder types: Other

Identifiers

NCT04047212

P12

Details and patient eligibility

About

Periodontitis is a widely prevalent disease worldwide that has serious public health consequences. Its prognosis includes tooth loss and edentulism, a condition that negatively affects chewing causing functional disability; and esthetics causing social impairment. Consequently, periodontitis may end up causing marked impairment of the quality of life of the affected patients, impairment of general health and increasing the dental care costs significantly.

Changes in the oral mucosa arise by primary products resulting from tissue breakdown due to gingivitis. It then triggers the host cells to produce proteinases that mediate loss of marginal periodontal ligaments, apical migration of the junctional epithelium and apical spread of bacterial biofilm.

Therefore, this research aims to identify the risk of smoking to both periodontitis and oral cancer, and the risk of periodontitis to oral cancer.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients 18 years or older.

Exclusion criteria

• Patients with any systemic diseases.
• Pregnant females.
• Handicapped and mentally retarded patients.
• Patients undergoing radiotherapy.
• Patients having oral cancer

Trial design

200 participants in 2 patient groups

Smokers

Treatment:

Diagnostic Test: periodontal examination

Diagnostic Test: biopsy for oral cancer

non-Smokers

Treatment:

Diagnostic Test: periodontal examination

Diagnostic Test: biopsy for oral cancer