The Longevity Genes in Founder Populations Project

Albert Einstein College of Medicine

Status: Enrolling

Conditions: Extreme Longevity

Study type: Observational

Funder types: Other; Industry; NIH

Identifiers

NCT00707694

P01AG021654 (U.S. NIH Grant/Contract)

1998-125

2U19AG056278-07A1 (U.S. NIH Grant/Contract)

3U19AG056278-06S1 (U.S. NIH Grant/Contract)

G42988 (Other Grant/Funding Number)

1R56AG088624-01 (U.S. NIH Grant/Contract)

R01AG088659 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

We believe extreme longevity is due to specific genes which function to delay aging and prevent disease. The purpose of the research is to identify the genes/mutations associated with healthier aging; to understand the biological functions of these genes/mutations; and to develop therapies to replicate these preservative genetic activities in individuals who do not have the genetic profile for longevity.

Enrollment: 2,000 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ashkenazi Jewish, age 95+,
• Offspring of person age 95+,
• Offspring of parents who died age 70 or younger.

Exclusion criteria

• Non-Ashkenazis

Trial design

2,000 participants in 3 patient groups

Probands

Description:

Ashkenazi Jews ages 95 and older

Offspring

Description:

Ashkenazi Jewish offspring of Ashkenazi Jewish parent(s) who lived to at least the age of 95

Controls

Description:

Ashkenazi Jewish people with no family history of longevity