The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders

The University of Texas System (UT)

Status: Active, not recruiting

Conditions: Neuromyelitis Optica; Neuromyelitis Optica Spectrum Disorder; Transverse Myelitis; Optic Neuritis

Study type: Observational

Funder types: Other

Identifiers

NCT01623076

STU 022012-084

Details and patient eligibility

About

This study seeks to determine the biologic causes of inflammation in patients with Transverse Myelitis (TM) Neuromyelitis Optica Spectrum Disorder (NMOSD) and related conditions. While patients will be treated according to decisions with their treating physician, this study will collect data and samples from patients prospectively to gain a better understanding of the disease. We are seeking to understand why some patients respond to medications, while others do not. We also seek to understand what happens biologically, preceding relapses. Gathering these data and samples will allow researchers to identify new ways of diagnosing and treating these diseases. Data and samples will be shared with researchers around the world to support collaborative efforts to treat these conditions.

Full description

This study seeks to determine the biologic causes of inflammation in patients with Neuromyelitis Optica (NMO), Transverse Myelitis (TM), optic neuritis (ON), related conditions and healthy controls. While patients will be treated according to decisions with their treating physician, this study will collect data and samples from patients prospectively to gain a better understanding of the disease. We are seeking to understand why some patients respond to medications, while others do not. We also seek to understand what happens biologically, preceding relapses. Gathering these data and samples will allow researchers to identify new ways of diagnosing and treating these diseases. Data and samples will be shared with researchers around the world to support collaborative efforts to treat these conditions.

Patients will agree to share medical records, complete questionnaires and donate samples on a timed basis.

Enrollment: 150 estimated patients

Sex: All

Ages: 6+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 6 years or greater
• Male or Female
• Patient or Parent (in the case of a minor) able to give informed consent
• For patients 10 to 17, patient able to assent
• Patient diagnosed with NMO, NMOSD, TM or ON

Exclusion criteria

• Unable to maintain scheduled visits
• Patient has known HIV or hepatitis C infection

Trial design

150 participants in 4 patient groups

Neuromyelitis Optica Spectrum Disorder

Description:

Patients diagnosed with NMOSD based on revised diagnostic criteria. Seronegative, anti-AQP4 seropositive and ant-MOG seropositive patients will be included

Transverse Myelitis and Optic Neuritis

Description:

Patients who have had one demyelinating event, not diagnosed with multiple sclerosis and whom are considered at risk for NMO or NMOSD.

Healthy Controls

Description:

patients without a history of CNS inflammation

Neuromyelitis Optica

Description:

patients diagnosed with NMO