The Lyon Real World Evidence in Metastatic NeuroEndocrine Tumours (LyREMeNet)

Civil Hospices of Lyon

Status: Unknown

Conditions: Metastatic Cancer; Gastro-enteropancreatic Neuroendocrine Tumor; Health Care Costs

Treatments: Other: Metastatic gastroenteropancreatic and lung neuroendocrine tumors

Study type: Observational

Funder types: Other

Identifiers

NCT03863106

LyREMeNet

Details and patient eligibility

About

Neuroendocrine tumours (NETs) are rare and include a heterogeneous group of neoplasms derived from the endocrine system found in the gastrointestinal tract, pancreas and lung. Gastroenteropancreatic (GEP) NETs represent the majority of neuroendocrine neoplasms (NEN) and the annual incidence of all GEP-NETs has been estimated to 6.98 per 100,000 person-years in 2012 and is steadily rising. While data on the incidence of metastatic GEP-NET is limited, more than 50% of patients with GEP-NET have metastatic disease at the time of diagnosis. Incorrect and delayed diagnoses are still common. Treatment options include surgery, locoregional interventions, and systemic treatment.

The Lyon Real world Evidence in Metastatic NeuroEndocrine Tumours study (LyREMeNET) is a descriptive observational cohort study. The main objective is to assess the healthcare resources use and the corresponding costs for management of patients with metastatic GEP and lung NETs. The secondary objective is to describe the clinical characteristics, prognostic factors, treatment patterns, and the overall survival among patients with metastatic GEP and lung NETs.

Enrollment: 880 estimated patients

Sex: All

Ages: 15 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with a diagnosis of well-differentiated metastatic neuroendocrine tumour (either synchronous or metachronous)
• Diagnosis performed between 1 January 1990 and 31 December of 2017
• Patients seen at least once at the oncologic department of Hospices Civils de Lyon.

Exclusion criteria

• Poorly differentiated neuroendocrine carcinoma
• Histologic mixed neuroendocrine tumour