The MEC90 of Epidural Ropivacaine Blunting Hemodynamic Changes to Pneumoperitoneum

Keimyung University

Status: Unknown

Conditions: Laparoscopic Gastrectomy

Treatments: Drug: Ropivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT04247373

2018-12-036

Details and patient eligibility

About

Investigators want to find the concentration of epidural ropivacaine, which can block hemodynamic changes in the onset of pneumoperitoneum in the laparoscopic gastrectomy.

Full description

According to previous patient's response, the investigators will allocate the concentration of ropivacaine of next patient during Co2 insufflation. And, for this allocation of concentration of ropivacaine, the investigators use biased coin design up-and-down method.

Based on the practices, the starting concentration is 0.375 %, and the step size of concentration is 0.125%.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing laparoscopic gastrectomy that require pneumoperitoneum
• patients who has epidural catheter to manage postoperative pain control
• patients who agree to our study

Exclusion criteria

• patients who don't agree to our study
• BMI<16.0 or BMI>35
• cardiovascular disease, pulmonary disease, renal disease
• alcoholic abuser or drug abuser
• any use of local anesthetics or drugs which have an influence on cardiovascular system from beginning of induction

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

laparoscopic gastrectomy with pneumoperitoneum

Experimental group

Treatment:

Drug: Ropivacaine