The Mechanism of Dexmedetomidine in Improving Delirium After Cardiac Surgery

Nanjing Medical University

Status: Unknown

Conditions: Cardiac Surgery; Delirium; Dexmedetomidine

Treatments: Drug: dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT04127500

KY20190823-04

Details and patient eligibility

About

The investigators aim to evaluate the roles of α7nAchR in the mechanisms of dexmedetomidine in improving delirium after cardiac surgery. The results of this study would lay the foundation for revealing the mechanisms of dexmedetomidine improving delirium after cardiac surgery and provide a new idea to the early treatment of delirium.

Enrollment: 200 estimated patients

Sex: All

Ages: 60 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ICU patients underwent cardiac surgery
• age ≥ 60 years

Exclusion criteria

• Preoperative cognitive decline, mental illness,
• preoperative long-term use of hormone patients,
• preoperative alcohol dependence,
• patients with alcohol withdrawal symptoms

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

200 participants in 2 patient groups

DEX group

Experimental group

Description:

use DEX

Treatment:

Drug: dexmedetomidine

control group

No Intervention group

Description:

use placebo