The Mechanisms of Diameter Changes in Retinal Vessels During Hypoxia

University of Aarhus

Status: Completed

Conditions: Retinal Hypoxia

Treatments: Drug: Nitroglycerin; Drug: COX-inhibitor + Nitroglycerin; Drug: COX-inhibitor

Study type: Interventional

Funder types: Other

Identifiers

NCT02059018

1-10-72-14-14 (Other Identifier)

HypNOCOX-2

Details and patient eligibility

About

The primary objective is to study if a stimulation of nitric oxide and/or prostaglandin affect the diameter changes of retinal vessels during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.

Enrollment: 20 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age between >19 and <61 years
• No known systemic or ocular diseases

Exclusion criteria

• Cardio-vascular disease
• Lung disease
• Epilepsy
• Previous ocular disease
• Previous treatment with medications influencing the intraocular pressure or the metabolism of nitric oxide or prostaglandins
• Daily intake of medicine except contraceptive pills
• Pregnancy or breastfeeding
• Known allergy against any of the drugs used in the interventions

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Hypoxia

Experimental group

Description:

Inhaling hypoxic gas mixture to induce hypoxemia during recordings of diameter changes of retinal vessels. Recording are performed during hypoxia alone and in combination with the associated interventions over two examination days

Treatment:

Drug: COX-inhibitor + Nitroglycerin

Drug: COX-inhibitor

Drug: Nitroglycerin

Normoxia

Experimental group

Description:

Breathing atmospheric air during recordings of diameter changes of retinal vessels. Recording are performed during normoxia alone and in combination with the associated interventions over two examination days

Treatment:

Drug: COX-inhibitor + Nitroglycerin

Drug: COX-inhibitor

Drug: Nitroglycerin