The Metabolic Effects of a High Fructose Versus a High Glucose Diet in Overweight Men

University of Nottingham

Status: Completed

Conditions: Hepatic Fatty Acid Metabolism; Oxidative Stress; Cardiovascular Status; Systemic Insulin Resistance

Treatments: Dietary Supplement: high sugar diet

Study type: Interventional

Funder types: Other

Identifiers

NCT01050140

D/10/2009

Details and patient eligibility

About

Dietary consumption of fructose has increased by nearly 50% since 1960.

A high fructose diet (HFrD) results in greater visceral adiposity and systemic insulin resistance than a high glucose diet. The effects of fructose on liver fatty acid and ATP stores, systemic oxidative stress and cardiovascular status are not fully known.

Full description

The protocol will assess the following outcomes:

1. The ultimate fate of this increased hepatic fatty acid production following a high fructose vs. glucose diet
2. The effect of a high fructose vs. glucose diet on liver ATP stores
3. The effect of a high fructose vs. glucose diet on markers of oxidative stress
4. The effect of a high fructose vs. glucose diet on cardiovascular status

Factors critical to carbohydrate metabolism such as systemic insulin resistance, body composition, energy expenditure, physical activity will also be assessed.

32 centrally overweight healthy males with a low baseline fructose intake will be recruited. They will be randomised double blindly to receive 25% of their dietary energy requirements from either fructose or glucose for 14 days.

The sugars will first be taken in an energy balanced and then an overfeeding setting.

Enrollment: 32 patients

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Body mass index 25-32
2. Waist > hip circumference
3. Age 18-50 years
4. Male

Exclusion criteria

1. Reported weight change > 3 kg in prior 3/12
2. Active health problems
3. Contraindications to MRI scanning
4. Symptoms of functional bloating or irritable bowel syndrome
5. Abnormal liver or renal function tests
6. Random glucose greater than 11.0 mmol/L
7. Evidence of metabolic or viral liver disease as screened for by hepatitis B and C serology, and ferritin.
8. Alcohol intake > 21 units per week
9. Vegetarianism
10. Normal daily fructose intake from drinks greater than that in 500ml of coca cola
11. Abnormal carbohydrate energy contribution to baseline diet - defined as greater than 2 standard deviations from the mean of the National Diet and Nutrition Survey 2002 data

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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32 participants in 2 patient groups

fructose

Experimental group

Description:

25% dietary energy from fructose

Treatment:

Dietary Supplement: high sugar diet

glucose

Active Comparator group

Description:

25% dietary energy from glucose

Treatment:

Dietary Supplement: high sugar diet